- The number of people with dementia in the world continues to increase, with 139 million people expected to have dementia by 2050.
- Certain people, including those with type 2 diabetes, are at increased risk of dementia.
- Researchers found that people with type 2 diabetes who took the diabetes drug pioglitazone were less likely to develop dementia later in life.
Certain people are at increased risk of developing dementia-related diseases.
Researchers at Yonsei University in Seoul, South Korea currently type 2 diabetes person taking diabetes medicine
This research recently neurologythe medical journal of the American Academy of Neurology.
Why are people with type 2 diabetes at increased risk of developing dementia?
according to Dr. Karen D. SullivanA board-certified neuropsychologist and owner of I CARE FOR YOUR BRAIN in Pinehurst, North Carolina, he says diabetes affects nearly every system in the body. brain.
“People with type 2 diabetes have a 50-60% higher risk of developing dementia compared to people without diabetes. This is one of the strongest modifiable risk factors for dementia,” she said. said. medical news today.
” insulin resistance seen in diabetes
In addition, type 2 diabetes is
“Two prospective neuropathological cohort studies suggested that diabetes lowers neuronal mass thresholds.
“The longer the duration of type 2 diabetes and the poorer control of the disease, the higher the risk of dementia.”
— Dr. Karen D. Sullivan
For this study, researchers
The analysis found that 8.3% of people who took pioglitazone developed dementia, compared to 10% of people with type 2 diabetes who did not take pioglitazone.
After considering certain lifestyle factors, scientists found that people with type 2 diabetes who took pioglitazone were 16% less likely to develop subsequent dementia.
The researchers noted the limitations of this study because it was based on information about insurance claims, so it’s possible that some people didn’t take pioglitazone even if they were prescribed it.
There is also no information in the study about the severity of illness in the participants
When asked how pioglitazone reduces the risk of developing dementia in people with type 2 diabetes, Dr. Kim EosProfessor of Psychiatry, Yonsei University School of Medicine, Seoul, Republic of Korea, and the lead author of the study .
“But based on [the] The basic pharmacological actions of this drug and findings from previous studies may suggest some,” he said. medical news today.
“First, basically the control Blood glucose level Beneficial for brain function. And the drug improves the metabolic capacity of the cells, allowing them to use bioenergetics more efficiently – in other words, it improves insulin resistance in the brain.
“Second, some studies have shown that pioglitazone clears the brain of a toxic protein called beta-amyloid.
“Thirdly, the drug was found to be more effective in diabetic patients who have problems with blood circulation. heart We speculate that pioglitazone’s nootropic effects may be related to improved vascular health,” he added.
As for the heart, during the study Dr. Kim and his team found that the strongest dementia-protective effect of pioglitazone was ischemic stroke again
Researchers found that people with a history of ischemic heart disease had a 54% reduced risk of developing dementia, and those who had an ischemic stroke had a 43% reduced risk.
Dr. Kim said he and his team were surprised by these results.
“It was an unexpected find,” he said.
“Ischemic heart or
As a next step in this research, Dr. Kim said he is conducting research to see how it is being used today.
“Clinical studies need prospective studies to confirm [the] Antidementia effects of this drug and the risk-benefit balance of using this drug. That is, [a] From a dementia prevention perspective, it’s about balancing the side effects and beneficial effects of long-term use of this drug,” he explained.
When asked what he would like to see next in this study, Dr. Sullivan said the next step for pioglitazone would be to assess its long-term safety in humans and maintain the observed benefits while reducing side effects. is to identify the optimal dose to
Pioglitazone is currently
Until then, Dr. Sullivan said the most important thing people with type 2 diabetes can do to lower their risk of dementia is to keep their blood sugar stable.hyperglycemia) and hypoglycemia (hypoglycemia) can damage blood vessels in the brain.
“We want our patients to avoid big highs and lows, and that’s when brain damage happens,” she said.
Tips for people with T2D
“Other evidence-based recommendations include: Aerobic 30 minutes daily, 5 days weekly, anti-inflammatory diet,Avoidance carbohydratesprioritize hydration,maintain healthy weightand management of other vascular risk factors high blood pressure, sleep apneaand high cholesterol”
— Dr. Karen D. Sullivan